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18 -- The type 2 diabetes drug Avandia (rosiglitazone) increases the risk of heart failure and death more than another drug in the same class, Actos (pioglitazone), new Canadian research contends. 12 issue of the Journal of the American Medical Association, as does another study, this one finding that Actos (pioglitazone), a diabetes drug in the same class as Avandia, actually reduces the risk of heart attack, stroke and death, even while it increases the risk for serious heart failure. If anything, deaths were reduced with rosiglitazone [Avandia] compared to those in the control group. Nissen, chairman of the Cleveland Clinic's department of cardiovascular medicine, reported a 43 percent increased risk of heart attack among patients taking Avandia (generic name rosiglitazone). Glucovance can also be combined with other diabetes drugs such as Avandia. Avandia has already been linked to an increased risk of heart failure.

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